The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 28, 2014

Filed:

Jun. 12, 2007
Applicants:

William Blakely, Silver Spring, MD (US);

Natalia Ossetrova, Sterling, VA (US);

Marcy Grace, Gaithersburg, MD (US);

Alexandra Miller, Hyattsville, MD (US);

Jean Mulimbi Muderhwa, San Antonio, TX (US);

Glen Manglapus, Bel Air, MD (US);

Inventors:

William Blakely, Silver Spring, MD (US);

Natalia Ossetrova, Sterling, VA (US);

Marcy Grace, Gaithersburg, MD (US);

Alexandra Miller, Hyattsville, MD (US);

Jean Mulimbi Muderhwa, San Antonio, TX (US);

Glen Manglapus, Bel Air, MD (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
G01N 33/573 (2006.01); G01N 33/567 (2006.01); A61K 49/00 (2006.01); C07K 16/24 (2006.01); G01N 33/569 (2006.01);
U.S. Cl.
CPC ...
C07K 16/248 (2013.01); A61K 49/0008 (2013.01); G01N 33/56972 (2013.01); G01N 2333/5412 (2013.01); G01N 2333/928 (2013.01); G01N 2333/82 (2013.01); A61K 49/0004 (2013.01); G01N 2800/40 (2013.01); G01N 2333/4737 (2013.01);
Abstract

Methods and kits are provided for assessing radiation injury and exposure in a subject. The methods comprise measuring the levels of at least two (2) protein biomarkers from different biological pathways and correlating the levels with an assessment of radiation injury and exposure. Additional use of peripheral blood cell counts and serum enzyme biomarkers, evaluated in the early time frame after a suspected radiation exposure, and use of integrated multiple parameter triage tools to enhance radiation exposure discrimination and assessment are also provided. The information obtained from such methods can be used by a clinician to accurately assess the extent of radiation injury/exposure in the subject, and thus will provide a valuable tool for determining treatment protocols on a subject by subject basis.


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