The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 28, 2014
Filed:
Mar. 10, 2010
Shinji Takeoka, Tokyo, JP;
Yousuke Obata, Chiba, JP;
Satoru Nakagawa, Toyama, JP;
Shinya Ohtsubo, Choufu, JP;
Yuji Kawasaki, Motosu, JP;
Shinji Takeoka, Tokyo, JP;
Yousuke Obata, Chiba, JP;
Satoru Nakagawa, Toyama, JP;
Shinya Ohtsubo, Choufu, JP;
Yuji Kawasaki, Motosu, JP;
Nanotheta Co, Ltd., Tokyo, JP;
Abstract
The present invention provides pH-responsive liposomes which are capable of holding a desired substance in an acidic pH environment and releasing the desired substance in a basic pH environment. The present invention uses pH-responsive liposomes comprising, as constituent lipids thereof, a cationic amphiphilic molecule and at least one of an anionic amphiphilic molecule and a twitterionic amphiphilic molecule, wherein the liposomes, when dispersed in an aqueous medium, have a positive zeta potential in an acidic environment where the dispersion has a pH of less than 6.5 and have a negative zeta potential in a basic environment where the dispersion has a pH of 8.5 or more.