The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 28, 2014

Filed:

Sep. 07, 2007
Applicants:

Harvey Friedman, Merion, PA (US);

Elizabeth E. Zumbrun, Middletown, MD (US);

Fushan Wang, Broomall, PA (US);

Inventors:

Harvey Friedman, Merion, PA (US);

Elizabeth E. Zumbrun, Middletown, MD (US);

Fushan Wang, Broomall, PA (US);

Assignee:
Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 39/245 (2006.01); A61P 31/22 (2006.01); C12N 15/38 (2006.01); C07K 14/03 (2006.01); C07K 14/035 (2006.01); C07K 14/005 (2006.01); C12N 7/00 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
A61K 39/245 (2013.01); C07K 14/005 (2013.01); C12N 2710/16661 (2013.01); A61K 2039/5254 (2013.01); C12N 2710/16634 (2013.01); C12N 2710/16622 (2013.01); C12N 7/00 (2013.01);
Abstract

This invention provides methods of vaccinating a subject against a Herpes Simplex Virus (HSV) infection and disorders and symptoms associated with same, and impeding, inhibiting, reducing the incidence of, and suppressing HSV infection, neuronal viral spread, formation of zosteriform lesions, herpetic ocular disease, herpes-mediated encephalitis, and genital ulcer disease in a subject, comprising the step of contacting the subject with a mutant strain of the HSV, containing an inactivating mutation in a gene encoding a gE, gI, Us9, or other proteins.


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