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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 8871184 B1

PDFFull Text
Date of Patent:
Oct. 28, 2014

Filed:

Oct. 01, 2010

Topical tetracycline compositions

Applicants:

Dov Tamarkin, Macabim, IL;

Elana Gazal, Rehovot, IL;

Yohan Hazot, Rehovot, IL;

David Schuz, Moshav, IL;

Rita Keynan, Rehovot, IL;

Nukri Papiashvili, Askelon, IL;

Inventors:

Dov Tamarkin, Macabim, IL;

Elana Gazal, Rehovot, IL;

Irakliy Papiashvili, Askelon, IL;

Yohan Hazot, Rehovot, IL;

David Schuz, Moshav, IL;

Rita Keynan, Rehovot, IL;

Assignee:

Foamix Ltd., Rehovot, IL;

Attorney:

Fish & Richardson P.C.

Primary Examiner:

Jeffrey T Palenik

Int. Cl.
CPC ...
A61K 8/18 (2006.01); A61K 35/50 (2006.01); A61K 31/65 (2006.01); C07C 50/36 (2006.01); C07C 237/26 (2006.01); A61K 31/4164 (2006.01); A61K 47/10 (2006.01); A61K 8/34 (2006.01); A61K 31/593 (2006.01); A61K 31/57 (2006.01); A61K 9/00 (2006.01); A61K 8/36 (2006.01); A61K 31/573 (2006.01); A61K 9/12 (2006.01); A61K 47/12 (2006.01);
U.S. Cl.
CPC ...
A61K 47/12 (2013.01); A61K 31/4164 (2013.01); A61K 47/10 (2013.01); A61K 8/342 (2013.01); A61K 31/593 (2013.01); A61K 31/57 (2013.01); A61K 9/0048 (2013.01); A61K 31/65 (2013.01); A61K 8/361 (2013.01); A61K 31/573 (2013.01); A61K 9/122 (2013.01); A61K 9/0014 (2013.01);
Abstract

A topical therapeutic hydrophobic breakable composition includes a carrier comprising (a) about 60% to about 99% by weight of at least one hydrophobic oil; (b) at least one viscosity-modifying agents selected from the group consisting of a fatty alcohol, a fatty acid and a wax; and (c) a tetracycline antibiotic, characterized in that at least part of the tetracycline antibiotic is suspended in the composition; the viscosity of the composition is at least about 30% higher than the viscosity of the carrier without the tetracycline antibiotic; and is higher than the viscosity of the hydrophobic oil and the tetracycline antibiotic without the viscosity modifying agents; and the amount of viscosity modifying agents can optionally be reduced by at least an amount by weight that would have increased the viscosity of the carrier without the tetracycline antibiotic by at least 30%; wherein the tetracycline is chemically stable in the composition for at least six months; wherein more than about 90% of the tetracycline has not broken down; wherein when packaged in an aerosol container to which is added a liquefied or compressed gas propellant the composition affords upon release from the container a breakable foam of at least good quality that breaks easily upon application of shear force.

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