The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 21, 2014

Filed:

Jun. 19, 2013
Applicant:

Bial-portela & C.a., S.a, S. Mamede do Coronado, PT;

Inventors:

Alexander Beliaev, S. Mamede do Coronado, PT;

David Alexander Learmonth, Alfena, PT;

Brian Broadbelt, Buckinghamshire, GB;

Ekaterina Albert, West Lafayette, IN (US);

Patricia Andres, West Lafayette, IN (US);

Assignee:

Bial-Portela & CA, S.A., S. Mamede Do Coronado, PT;

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 233/54 (2006.01); C07D 405/04 (2006.01);
U.S. Cl.
CPC ...
C07D 405/04 (2013.01);
Abstract

The present invention relates to crystalline Form A of 1-[(3R)-6,8-difluoro-3,4-dihydro-2H-1-benzopyran-3-yl]-1,3-dihydro-5-[2-[(phenylmethyl)amino]ethyl]-2H-imidazole-2-thione and crystalline Form B of 1-[(3R)-6,8-difluoro-3,4-dihydro-2H-1-benzopyran-3-yl]-1,3-dihydro-5-[2-[(phenylmethyl)amino]ethyl]-2H-imidazole-2-thione, processes for preparing the forms and their uses in medicine. The present invention also relates to the amorphous form of 1-[(3R)-6,8-difluoro-3,4-dihydro-2H-1-benzopyran-3-yl]-1,3-dihydro-5-[2-[(phenylmethyl)amino]ethyl]-2H-imidazole-2-thione processes for preparing it and its uses in medicine.


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