The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 21, 2014
Filed:
Apr. 02, 2012
David Hockenbery, Seattle, WA (US);
Julian Simon, Seattle, WA (US);
David Hockenbery, Seattle, WA (US);
Julian Simon, Seattle, WA (US);
Fred Hutchinson Cancer Research Center, Seattle, WA (US);
Abstract
Compounds are described that are useful for treating an apoptosis-associated disease, which are specifically cytotoxic to tumor cells that are overexpressing Bcl-x, and are much less cytotoxic in isogenic cells that are not overexpressing Bcl-x. Also described is a method for treating an apoptosis-associated disease in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of an active compound that is specifically cytotoxic to tumor cells that are overexpressing Bcl-x, and are much less cytotoxic in isogenic cells that are not overexpressing Bcl-x. Several scaffolds of active compounds are described.