The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 21, 2014
Filed:
Jan. 13, 2012
Applicant:
Ben DE Lange, Echt, NL;
Inventor:
Ben De Lange, Echt, NL;
Assignee:
DSM Sinochem Pharmaceuticals Netherlands B.V., Delft, NL;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D 239/02 (2006.01); C07D 257/00 (2006.01); C07D 405/06 (2006.01); C07D 405/12 (2006.01); C07D 413/12 (2006.01); C07D 405/14 (2006.01); C07D 419/12 (2006.01);
U.S. Cl.
CPC ...
C07D 405/12 (2013.01); C07D 405/06 (2013.01); C07D 413/12 (2013.01); C07D 405/14 (2013.01); C07D 419/12 (2013.01);
Abstract
The present invention relates to a process for the preparation of a 1-methyl-1H-tetrazole-5-thio derivative comprising reaction of a halomethyl substrate with 1-methyl-H-tetrazole-5-thiol to obtain a thio-ether compound, and oxidizing the thio-ether compound to the corresponding sulfone. In case of a chiral halomethyl substrate, the resulting chiral diol sulfone derivative is suitable as a building block for statin type compounds.