The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 21, 2014
Filed:
Jun. 25, 2013
Applicant:
The Ohio State University Research Foundation, Columbus, OH (US);
Inventors:
Carlo M. Croce, Columbus, OH (US);
Ramiro Garzon, Columbus, OH (US);
George A. Calin, Pearland, TX (US);
Assignee:
The Ohio State University Research Foundation, Columbus, OH (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07H 21/04 (2006.01); C12N 15/113 (2010.01); C12Q 1/68 (2006.01); A61K 45/06 (2006.01); A61K 31/7105 (2006.01);
U.S. Cl.
CPC ...
C12N 15/1135 (2013.01); C12Q 2600/178 (2013.01); C12Q 2600/106 (2013.01); C12Q 1/6883 (2013.01); A61K 45/06 (2013.01); C12Q 1/6886 (2013.01); A61K 31/7105 (2013.01); C12N 15/113 (2013.01);
Abstract
Described herein is a pharmaceutical composition for treating a subject having a cancer and/or myeloproliferative disorder associated with overexpression of a HOXA1 gene product where an effective amount of at least one miR-10a gene product or an isolated variant or biologically-active fragment thereof is administered to the subject sufficient to decrease expression of the HOXA1 gene product in the subject.