The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 21, 2014
Filed:
Aug. 19, 2008
Applicants:
Jie Liu, Palo Alto, CA (US);
David King, Solana Beach, CA (US);
Inventors:
Jie Liu, Palo Alto, CA (US);
David King, Solana Beach, CA (US);
Assignee:
Medarex, L.L.C., Princeton, NJ (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/00 (2006.01); C07K 16/46 (2006.01); A61K 47/48 (2006.01); C07K 16/28 (2006.01); C07K 16/30 (2006.01);
U.S. Cl.
CPC ...
C07K 16/2875 (2013.01); A61K 47/48638 (2013.01); A61K 47/48446 (2013.01); A61K 47/48392 (2013.01); A61K 47/48715 (2013.01); C07K 2317/21 (2013.01); A61K 47/48384 (2013.01); C07K 16/3069 (2013.01);
Abstract
The present invention provides antibodies (e.g., IgG antibodies) having C-terminal cysteine-containing extensions that facilitate antibody conjugation to a partner molecule (e.g. a drug, toxin, marker molecule, protein, radioisotope, or other therapeutic agent). Methods of making, screening and selecting the antibodies of the invention are provided.