The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 21, 2014
Filed:
May. 06, 2011
Raymond J. Deshaies, Claremont, CA (US);
Tsui-fen Chou, Pasadena, CA (US);
Frank J. Schoenen, Lawrence, KS (US);
Kelin LI, Lawrence, KS (US);
Kevin J. Frankowski, Lawrence, KS (US);
Jeffrey Aube, Lawrence, KS (US);
Samuel W. Gerritz, Guilford, CT (US);
Han-jie Zhou, Foster City, CA (US);
Raymond J. Deshaies, Claremont, CA (US);
Tsui-Fen Chou, Pasadena, CA (US);
Frank J. Schoenen, Lawrence, KS (US);
Kelin Li, Lawrence, KS (US);
Kevin J. Frankowski, Lawrence, KS (US);
Jeffrey Aube, Lawrence, KS (US);
Samuel W. Gerritz, Guilford, CT (US);
Han-Jie Zhou, Foster City, CA (US);
California Institute of Technology, Pasadena, CA (US);
The University of Kansas, Lawrence, KS (US);
Cleave Biosciences, Inc., Burlingame, CA (US);
Abstract
Compounds of Formulas I-XLIII are identified as direct inhibitors of p97 ATPase or of the degradation of a p97-dependent ubiquitin-proteasome system (UPS) substrate. Methods and compositions are disclosed for inhibiting p97 ATPase and the degradation of a p97-dependent UPS substrate, and for identifying inhibitors thereof.