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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 8865704 B1

PDFFull Text
Date of Patent:
Oct. 21, 2014

Filed:

Oct. 06, 2010

Wnt pathway antagonists

Applicants:

Maurizio Varrone, Siena, IT;

Arianna Nencini, Siena, IT;

Joanna Margaret Quinn, Siena, IT;

Andrea Caricasole, Siena, IT;

Annette Cornelia Bakker, Sienna, IT;

Giovanni Gaviraghi, Siena, IT;

Massimilano Salerno, Siena, IT;

Inventors:

Maurizio Varrone, Siena, IT;

Arianna Nencini, Siena, IT;

Joanna Margaret Quinn, Siena, IT;

Andrea Caricasole, Siena, IT;

Annette Cornelia Bakker, Sienna, IT;

Giovanni Gaviraghi, Siena, IT;

Massimilano Salerno, Siena, IT;

Assignee:

Siena Biotech S.p.A., Siena, IT;

Attorney:

Arent Fox LLP

Primary Examiner:

Bruck Kifle

Int. Cl.
CPC ...
C07D 217/14 (2006.01); C07D 235/26 (2006.01); C07D 239/22 (2006.01); C07D 239/80 (2006.01); C07D 239/96 (2006.01); A61K 31/4166 (2006.01); A61K 31/4184 (2006.01); A61K 31/437 (2006.01); A61K 31/472 (2006.01); A61K 31/517 (2006.01); A61K 31/5377 (2006.01); A61K 31/5513 (2006.01); C07D 471/04 (2006.01); C07D 417/12 (2006.01); C07D 243/10 (2006.01); C07D 403/12 (2006.01); C07D 407/12 (2006.01); C07D 409/12 (2006.01); C07D 413/08 (2006.01); C07D 401/12 (2006.01); C07D 405/12 (2006.01);
U.S. Cl.
CPC ...
C07D 217/14 (2013.01); C07D 239/22 (2013.01); C07D 471/04 (2013.01); C07D 417/12 (2013.01); C07D 243/10 (2013.01); C07D 403/12 (2013.01); C07D 407/12 (2013.01); C07D 235/26 (2013.01); C07D 239/80 (2013.01); C07D 409/12 (2013.01); C07D 239/96 (2013.01); C07D 413/08 (2013.01); C07D 401/12 (2013.01); C07D 405/12 (2013.01);
Abstract

The present invention relates to known and novel compounds of formula (I) as herein described and pharmaceutical compositions thereof. The compounds of formula (I) have inhibitory effect on the Wnt pathway and are therefore useful in the preparation of a medicament, in particular for the treatment of cancer.

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