The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 21, 2014
Filed:
May. 12, 2011
James Heyes, Vancouver, CA;
Mark Wood, Port Moody, CA;
Alan Martin, Vancouver, CA;
Amy C. H. Lee, Burnaby, CA;
Adam Judge, Vancouver, CA;
Marjorie Robbins, Vancouver, CA;
Ian Maclachlan, Mission, CA;
James Heyes, Vancouver, CA;
Mark Wood, Port Moody, CA;
Alan Martin, Vancouver, CA;
Amy C. H. Lee, Burnaby, CA;
Adam Judge, Vancouver, CA;
Marjorie Robbins, Vancouver, CA;
Ian MacLachlan, Mission, CA;
Protiva Biotherapeutics, Inc., Burnaby, British Columbia, CA;
Abstract
The present invention provides compositions and methods for the delivery of interfering RNAs such as siRNAs that silence APOB expression in cells such as liver cells. In particular, the nucleic acid-lipid particles provide efficient encapsulation of nucleic acids and efficient delivery of the encapsulated nucleic acid to cells such as liver cells in vivo. The compositions of the present invention are highly potent, thereby allowing effective knock-down of APOB at relatively low doses. In addition, the compositions and methods of the present invention are less toxic and provide a greater therapeutic index compared to compositions and methods previously known in the art.