The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 21, 2014
Filed:
May. 18, 2011
Christophe Cazaux, Plaisance du Touch, FR;
Jean-sébastien Hoffmann, Toulouse, FR;
Jean-christophe Bourdon, Dundee, GB;
Alice Machado Da Silva, Belo Horizonte, BR;
Henri Roche, Pibrac, FR;
Christophe Cazaux, Plaisance du Touch, FR;
Jean-Sébastien Hoffmann, Toulouse, FR;
Jean-Christophe Bourdon, Dundee, GB;
Alice Machado Da Silva, Belo Horizonte, BR;
Henri Roche, Pibrac, FR;
Centre National de la Recherche Scientifique (CNRS), Paris, FR;
Universite Paul Sabatier Toulouse III, Toulouse, FR;
Institut Claudius Regaud, Toulouse, FR;
Abstract
The present invention relates to a method for diagnosing aggressiveness and/or genetic instability of a cancer in a patient from a cancer sample of the patient. The method includes measuring in vitro the expression level of the POLQ gene and the expression level of a control gene in the patient cancer sample, calculating an expression level ratio of the expression level of POLQ to the expression of the control gene in the patient cancer sample, comparing the expression level ratio to a corresponding threshold value, and diagnosing cancer aggressiveness and genetic instability if the POLQ expression level ratio is superior to a corresponding threshold value. Dedicated microarrays and kits are also described, as well as a method of selecting a suitable treatment.