The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 21, 2014

Filed:

Feb. 11, 2009
Applicants:

Yechezkel Barenholz, Jerusalem, IL;

Dganit Danino, Nesher, IL;

Inventors:

Yechezkel Barenholz, Jerusalem, IL;

Dganit Danino, Nesher, IL;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 9/14 (2006.01); A61K 9/16 (2006.01); A61K 9/50 (2006.01); A23L 1/305 (2006.01); A23J 1/22 (2006.01); A23B 4/03 (2006.01); A61K 31/665 (2006.01); A61K 31/415 (2006.01); A61K 9/00 (2006.01); A61K 9/107 (2006.01); A61K 31/573 (2006.01);
U.S. Cl.
CPC ...
A61K 9/00 (2013.01); A61K 9/1075 (2013.01); A61K 31/415 (2013.01); A61K 31/573 (2013.01);
Abstract

Nanoparticulate assemblies of isolated beta-casein, are useful for encapsulation of bioactive therapeutic substances, particularly therapeutic agents with poor bioavailability. These nano-sized beta-casein assemblies are preferably formed at pH values which are at least one or more pH units below or above the pI of the protein. Pharmaceutical compositions comprising the beta-casein micelles may be used to administer the agents to the GI tract for treatment of local or systemic conditions. These carriers are stable over a wide temperature range (optionally at least from about 1° C. to at least about 45° C.).


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