The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 21, 2014
Filed:
Jun. 14, 2010
Mei-ling Ho, Kaohsiung, TW;
Gwo-jaw Wang, Taipei, TW;
Je-ken Chang, Kaohsiung, TW;
Yin-chih Fu, Kaohsiung, TW;
Cherng-chyi Tzeng, Kaohsiung, TW;
Eswaramoorthy Rajalakshmanan, Kaohsiung, TW;
Mei-Ling Ho, Kaohsiung, TW;
Gwo-Jaw Wang, Taipei, TW;
Je-Ken Chang, Kaohsiung, TW;
Yin-Chih Fu, Kaohsiung, TW;
Cherng-Chyi Tzeng, Kaohsiung, TW;
Eswaramoorthy Rajalakshmanan, Kaohsiung, TW;
Kaohsiung Medical University, Kaohsiung, TW;
Abstract
The present invention provides a method for producing a controlled release microsphere with mean average size greater than 50 μm, comprising preparing a water-in-oil (w/o) emulsion comprising an inner aqueous layer containing a pharmaceutically effective amount of a biologically active polypeptide with activity similar to parathyroid hormone, and an oil layer containing a polymer substance of poly(lactic-co-glycolic acid) (PLGA), then adding the w/o emulsion into aqueous polyvinyl alcohol (PVA) solution to form a water-in-oil-in-water (w/o/w) double emulsion and then desorbing the solvent in the oil layer. The present invention also provides a controlled release microsphere prepared by the method and use thereof.