The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 21, 2014
Filed:
Sep. 10, 2012
Miguel DE Los Rios, Del Mar, CA (US);
Stephanie DE Los Rios, Del Mar, CA (US);
Jacek Ostrowski, Encinitas, CA (US);
Kenneth J. OH, Pleasant Hill, CA (US);
Ilan Zipkin, Belmont, CA (US);
Miguel de los Rios, Del Mar, CA (US);
Stephanie de los Rios, Del Mar, CA (US);
Jacek Ostrowski, Encinitas, CA (US);
Kenneth J. Oh, Pleasant Hill, CA (US);
Ilan Zipkin, Belmont, CA (US);
Biomed Realty, L.P., San Diego, CA (US);
Abstract
Provided herein are methods and compositions for controlling assembly of modified viral core proteins, for example, into a viral capsid or a nanocage. In some embodiments, the disclosed modified viral core proteins comprise at least one mutation or modification that can substantially prevent assembly of the viral core proteins until assembly is desired. In some embodiments, assembly of the viral core proteins may be triggered, for example, by contacting the viral core proteins with a reducing agent and/or by reducing the concentration of a denaturant. The viral core proteins may self-assemble to form a viral capsid or nanocage.