The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 14, 2014
Filed:
Mar. 08, 2006
Ioanna Andreou, Cologne, DE;
Stefan Pitsch, Zürich, CH;
Evelyne Muller, Lausanne, CH;
Luc Reymond, Chavannes, CH;
Ioanna Andreou, Cologne, DE;
Stefan Pitsch, Zürich, CH;
Evelyne Muller, Lausanne, CH;
Luc Reymond, Chavannes, CH;
QIAGEN GmbH, Hilden, DE;
Abstract
The present invention refers to a double-stranded siRNA molecule comprising a sense Strand and an antisense Strand which is essentially complementary to the sense Strand, each of the sense and the antisense Strands comprising at least 17 nucleotides (nt), the siRNA further comprising at least one overhang at the 5' and/or 3′ end, wherein the overhang residue or overhang residues are chemically modified and selected independently from each other from the group consisting of: (a) 2′-deoxy modified nucleotides; (b) 2′-methoxy modified nucleotides; (c) two nucleosides linked by a 3′ to 5′ or 2′ to 5′ formacetal linkage; (d) nucleotides modified at the 2′-position by a —O—CH—O—(CH)—OH group; and (e) nucleotides comprising in the 3′-position a —CH—O—(CH)—CHgroup.