The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 14, 2014
Filed:
Oct. 13, 2003
Jacobus Johannes Maria Van Dongen, Vorden, NL;
Anthonie Willem Langerak, Barendrecht, NL;
Eduardus Maria Dominicus Schuuring, Groningen, NL;
Jesus Fernando San Miquel, Salamanca, ES;
Ramon Garcia Sanz, Salamanca, ES;
Antonio Parreira, Lisbon, PT;
John Lewis Smith, Wilts, GB;
Frances Louise Lavender, Hants, GB;
Gareth John Morgan, Surrey, GB;
Paul Anthony Stuart Evans, West Yorkshire, GB;
Michael Kneba, Westensee, DE;
Michael Hummel, Berlin, DE;
Elizabeth Anne Macintyre, Meudon, FR;
Christian Bastard, Ardouval, FR;
Jacobus Johannes Maria Van Dongen, Vorden, NL;
Anthonie Willem Langerak, Barendrecht, NL;
Eduardus Maria Dominicus Schuuring, Groningen, NL;
Jesus Fernando San Miquel, Salamanca, ES;
Ramon Garcia Sanz, Salamanca, ES;
Antonio Parreira, Lisbon, PT;
John Lewis Smith, Wilts, GB;
Frances Louise Lavender, Hants, GB;
Gareth John Morgan, Surrey, GB;
Paul Anthony Stuart Evans, West Yorkshire, GB;
Michael Kneba, Westensee, DE;
Michael Hummel, Berlin, DE;
Elizabeth Anne Macintyre, Meudon, FR;
Christian Bastard, Ardouval, FR;
Other;
Abstract
The invention relates to PCR-based clonality studies for among others early diagnosis of lymphoproliferative disorders. Provided is a set of nucleic acid amplification primers comprising a forward primer, or a variant thereof, and a reverse primer, or a variant thereof, capable of amplifying a rearrangement selected from the group consisting of a VH-JH IGH rearrangement, a DH-JH IGH rearrangement, a VK-JK IGK rearrangement, a VK/intron-Kde IGK rearrangement, a Vλ-Jλ IGL rearrangement, a Vβ-Jβ TCRB rearrangement, a Dβ-Jβ TCRB rearrangement, a Vγ-Jγ TCRG rearrangement, a Vδ-Jδ TCRD rearrangement, a Dδ-Dδ TCRD rearrangement, a Dδ-Jδ TCRD rearrangement, a Vδ-Dδ TCRD rearrangement, or a translocation selected from t(11;14)(BCL1-IGH) and t(14;18)(BCL2-IGH). The primers can be used in PCR-based clonality studies for early diagnosis of lymphoproliferative disorders and detection of minimal residual disease (MRD). Also provided is a kit comprising at least one set of primers of the invention.