The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 14, 2014
Filed:
Sep. 16, 2011
Applicants:
Roland Kontermann, Nurtingen, DE;
Klaus Pfizenmaier, Tiefenbronn, DE;
Andreas Herrmann, Pfeffingen, CH;
Kirstin Zettlitz, Sherman Oaks, CA (US);
Inventors:
Roland Kontermann, Nurtingen, DE;
Klaus Pfizenmaier, Tiefenbronn, DE;
Andreas Herrmann, Pfeffingen, CH;
Kirstin Zettlitz, Sherman Oaks, CA (US);
Assignee:
Baliopharm AG, Basel, CH;
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12P 21/08 (2006.01); A61K 39/00 (2006.01); A61K 39/395 (2006.01); C07K 16/28 (2006.01);
U.S. Cl.
CPC ...
C07K 16/2866 (2013.01); C07K 2317/41 (2013.01); C07K 2317/56 (2013.01); C07K 16/2878 (2013.01); C07K 2317/76 (2013.01); C07K 2317/24 (2013.01); C07K 2317/92 (2013.01); C07K 2317/71 (2013.01);
Abstract
The disclosure to an anti-huTNFR1 antibody of the IgG1 type, which has a modified Fc region deficient in mediating effector function, a pharmaceutical preparation comprising such antibody, and an anti-huTNFR1 antibody of the IgG1 type for use as a TNF antagonist without forming an agonistic TNFR1 signalling complex, as an alternative to treatment with an anti-TNF therapeutic.