The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 14, 2014
Filed:
Aug. 12, 2009
Applicant:
Xuechen LI, Hong Kong, CN;
Inventor:
Xuechen Li, Hong Kong, CN;
Assignee:
Other;
Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K 2/00 (2006.01); C07K 1/00 (2006.01); C07K 1/107 (2006.01); C07K 5/103 (2006.01); C07K 5/062 (2006.01); C07K 5/083 (2006.01); C07K 7/06 (2006.01); C07K 14/00 (2006.01); C07K 5/078 (2006.01); C07K 5/097 (2006.01);
U.S. Cl.
CPC ...
C07K 1/1075 (2013.01); C07K 5/101 (2013.01); C07K 5/06052 (2013.01); C07K 5/0808 (2013.01); C07K 7/06 (2013.01); C07K 14/001 (2013.01); C07K 5/06165 (2013.01); C07K 5/0823 (2013.01);
Abstract
A chemoselective chemical ligation method is disclosed. The method joins two peptide segments efficiently to produce a larger peptide or protein, by generating a natural peptide bond (Xaa-Ser and Xaa-Thr) at the ligation site (Xaa represents any 5 amino acid). The method requires two steps (FIG.()): a) reacting the starting peptide(s) to form an acetal intermediate with an acetal group at the ligation site; b) converting said acetal intermediate to a desired peptide or protein with said natural peptide bond.