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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 8859615 B1

PDFFull Text
Date of Patent:
Oct. 14, 2014

Filed:

Aug. 27, 2009

Compounds, compositions and methods for reducing toxicity and treating or preventing diseases

Applicants:

Samuel J. Danishefsky, Englewood, NJ (US);

Ting-chao Chou, Paramus, NJ (US);

Xiaoguang Lei, Chao Yang, CN;

Heedong Yun, Tenafly, NJ (US);

Fay NG, New York, NY (US);

John Hartung, New York, NY (US);

Dalibor Sames, New York, NY (US);

Inventors:

Samuel J. Danishefsky, Englewood, NJ (US);

Ting-Chao Chou, Paramus, NJ (US);

Xiaoguang Lei, Chao Yang, CN;

Heedong Yun, Tenafly, NJ (US);

Fay Ng, New York, NY (US);

John Hartung, New York, NY (US);

Dalibor Sames, New York, NY (US);

Assignee:

Other;

Attorney:

Ostrolenk Faber LLP

Primary Examiner:

Rebecca Anderson

Assistant Examiner:

Karen Cheng

Int. Cl.
CPC ...
A61K 31/191 (2006.01); A61K 31/357 (2006.01); C07C 31/22 (2006.01); C07D 317/12 (2006.01); C07C 33/048 (2006.01); A61K 31/047 (2006.01); A61K 31/075 (2006.01); A61K 31/165 (2006.01); A61K 31/196 (2006.01); A61K 31/337 (2006.01); A61K 31/343 (2006.01); A61K 31/4192 (2006.01); A61K 31/427 (2006.01); A61K 31/661 (2006.01); A61K 31/675 (2006.01); A61K 31/7048 (2006.01); A61K 45/06 (2006.01); C07C 33/05 (2006.01); C07C 33/14 (2006.01); C07C 33/30 (2006.01); C07C 43/315 (2006.01); C07C 49/24 (2006.01); C07D 249/04 (2006.01); C07D 317/16 (2006.01); C07D 317/18 (2006.01); C07D 317/20 (2006.01); C07D 317/22 (2006.01); C07D 317/24 (2006.01); C07D 317/26 (2006.01); C07D 317/28 (2006.01); C07D 317/30 (2006.01);
U.S. Cl.
CPC ...
C07C 33/048 (2013.01); A61K 31/047 (2013.01); A61K 31/075 (2013.01); A61K 31/165 (2013.01); A61K 31/196 (2013.01); A61K 31/337 (2013.01); A61K 31/343 (2013.01); A61K 31/357 (2013.01); A61K 31/4192 (2013.01); A61K 31/427 (2013.01); A61K 31/661 (2013.01); A61K 31/675 (2013.01); A61K 31/7048 (2013.01); A61K 45/06 (2013.01); C07C 33/05 (2013.01); C07C 33/14 (2013.01); C07C 33/30 (2013.01); C07C 43/315 (2013.01); C07C 49/24 (2013.01); C07D 249/04 (2013.01); C07D 317/16 (2013.01); C07D 317/18 (2013.01); C07D 317/20 (2013.01); C07D 317/22 (2013.01); C07D 317/24 (2013.01); C07D 317/26 (2013.01); C07D 317/28 (2013.01); C07D 317/30 (2013.01); C07B 2200/07 (2013.01); C07C 2101/02 (2013.01); C07C 2101/14 (2013.01);
Abstract

The present invention provides compounds of Formula (I), compositions comprising an effective amount of a compound of Formula (I), optionally with chemotherapeutic drugs such as a tubulin-binding drug, and methods of their use for reducing the toxicity of cytotoxic agents, treating or preventing cancer or a neuropathic disorder, inducing a chemoprotective phase II enzyme, DNA, or protein synthesis, enhancing the immune system, treating inflammation, improving and enhancing general health or well-being, and methods for making compounds of Formula (I).

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