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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 8859529 B1

PDFFull Text
Date of Patent:
Oct. 14, 2014

Filed:

Sep. 22, 2009

Compounds for the treatment of inflammatory disorders

Applicants:

Bandarpalle B. Shankar, Branchburg, NJ (US);

Seong Heon Kim, Livington, NJ (US);

Wensheng Yu, Edison, NJ (US);

Ling Tong, Warren, NJ (US);

Michael K. C. Wong, Somerset, NJ (US);

Brian J. Lavey, New Providence, NJ (US);

Joseph A. Kozlowski, Princeton, NJ (US);

Lei Chen, Roselle Park, NJ (US);

Razia K. Rizvi, Bloomfield, NJ (US);

Aneta Maria Kosinski, South Amboy, NJ (US);

De-yi Yang, Morris Plains, NJ (US);

Guowei Zhou, Somerset, NJ (US);

Kristen E. Rosner, Watertown, NJ (US);

Luke Fire, Cambridge, MA (US);

Judson E. Richard, Kittery, ME (US);

Dansu LI, Reading, MA (US);

Inventors:

Bandarpalle B. Shankar, Branchburg, NJ (US);

Seong Heon Kim, Livington, NJ (US);

Wensheng Yu, Edison, NJ (US);

Ling Tong, Warren, NJ (US);

Michael K. C. Wong, Somerset, NJ (US);

Brian J. Lavey, New Providence, NJ (US);

Joseph A. Kozlowski, Princeton, NJ (US);

Lei Chen, Roselle Park, NJ (US);

Razia K. Rizvi, Bloomfield, NJ (US);

Aneta Maria Kosinski, South Amboy, NJ (US);

De-Yi Yang, Morris Plains, NJ (US);

Guowei Zhou, Somerset, NJ (US);

Kristen E. Rosner, Watertown, NJ (US);

Luke Fire, Cambridge, MA (US);

Judson E. Richard, Kittery, ME (US);

Dansu Li, Reading, MA (US);

Assignee:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Attorneys:

Eric A. Meade

Valerie J. Camara

Primary Examiner:

Samantha Shterengarts

Int. Cl.
CPC ...
C07D 205/06 (2006.01); C07D 413/14 (2006.01); C07D 239/02 (2006.01); C07D 401/14 (2006.01); C07F 9/02 (2006.01); C07D 491/04 (2006.01); C07D 471/02 (2006.01); C07D 233/54 (2006.01); C07D 403/14 (2006.01); A61K 31/675 (2006.01); A61K 31/397 (2006.01); A61K 31/5377 (2006.01); A61K 31/497 (2006.01); A61K 31/505 (2006.01); A61K 31/4427 (2006.01); A61K 31/4155 (2006.01); C07D 405/14 (2006.01); C07D 403/06 (2006.01); C07D 491/048 (2006.01);
U.S. Cl.
CPC ...
C07D 403/14 (2013.01); C07D 405/14 (2013.01); C07D 403/06 (2013.01); C07D 491/048 (2013.01);
Abstract

This invention relates to compounds of the Formula (I) as described herein, or a pharmaceutically acceptable salt, solvate or ester thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF- or combinations thereof.

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