The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 14, 2014
Filed:
May. 12, 2012
James A. Cowan, Delaware, OH (US);
Ada S. Cowan, Delaware, OH (US);
Donna T. Palmer, San Diego, CA (US);
James A. Cowan, Delaware, OH (US);
Ada S. Cowan, Delaware, OH (US);
Donna T. Palmer, San Diego, CA (US);
MetalloPharm, LLC, Delaware, OH (US);
Abstract
It is an object of the present invention to provide improved pharmacological properties to molecules which bind to a target with low affinity (hereinafter referred to as a 'ligand moiety') through linkage of such molecules to a metal binding moiety, thereby generating a combination molecule commonly referred to as a 'metallodrug' or “metallotherapeutic.” The metal binding domain of metallodrugs typically catalyzes oxido-reductase chemistry or acts as a Lewis-Acid catalyst, resulting in modification of proteins and nucleic acids that are in close proximity due to binding of the ligand moiety to its target.