The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 14, 2014

Filed:

Aug. 11, 2010
Applicants:

Franz Kaufmann, Freiburg, DE;

Trine Hefsgaard Miller, Aesch, CH;

Johannes Flothmann, Basel, CH;

Beate Winter, Steinen, DE;

Andreas Hafner, Gelterkinden, CH;

Inventors:

Franz Kaufmann, Freiburg, DE;

Trine Hefsgaard Miller, Aesch, CH;

Johannes Flothmann, Basel, CH;

Beate Winter, Steinen, DE;

Andreas Hafner, Gelterkinden, CH;

Assignee:

BASF SE, Ludwigshafen, DE;

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12P 21/00 (2006.01); C07K 14/54 (2006.01); C12P 21/02 (2006.01); C12N 1/38 (2006.01);
U.S. Cl.
CPC ...
C12N 1/38 (2013.01); C12P 21/02 (2013.01);
Abstract

A method for the manufacture of products by biotechnological methods in bacterial cell culture is disclosed as well as products obtained, the use of certain additives to the media used in the manufacture of said products in bacterial cell culture media, and the use of said additives in reducing the detrimental effects of radicals in the manufacture of the products, as well as aspects related to these invention embodiments. The manufacturing process or method comprises adding one or more radical scavenging and/or antioxidative additive preferably selected from the group consisting of sterically hindered nitroxyls, sterically hindered hydroxylamines, sterically hindered hydroxylamine salt compounds, sterically hindered amino compounds and sterically hindered N-hydrocarbyloxyamines, benzofuranone compounds, as obligatory component(s) to the medium used during biosynthesis.


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