The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 14, 2014
Filed:
Jul. 30, 2012
Lijuan Zhang, Hong Kong, HK;
LI Ling, Hong Kong, HK;
LI Ying Zhou, Hong Kong, HK;
Zhi Min Wu, Hong Kong, HK;
Xin Dong Guo, Hong Kong, HK;
Wei Jiang, Hong Kong, HK;
Qian Luo, Hong Kong, HK;
Yu Qian, Hong Kong, HK;
Lijuan Zhang, Hong Kong, HK;
Li Ling, Hong Kong, HK;
Li Ying Zhou, Hong Kong, HK;
Zhi Min Wu, Hong Kong, HK;
Xin Dong Guo, Hong Kong, HK;
Wei Jiang, Hong Kong, HK;
Qian Luo, Hong Kong, HK;
Yu Qian, Hong Kong, HK;
Nano and Advanced Materials Institute Limited, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, HK;
Abstract
The present invention discloses the pH-sensitive nanoparticles composed of pH-sensitive polymer, hydrophobic material, internal stabilizer, external stabilizer content and insulin drug. The present invention also includes a method for preparation of pH-sensitive nanoparticles, in particular, a multiple emulsions solvent evaporation method. The pH-sensitive nanoparticles of the present invention show good pH-sensitive property with 100-300 nanometer particle size. Significant decrease in blood glucose level is observed in streptozotocin (STZ)-induced diabetic rats and the bioavailability of insulin is more than 10% after oral administration of the insulin-loaded pH-sensitive nanoparticles.