The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 14, 2014
Filed:
Jan. 02, 2008
Applicants:
Ralph Leon Biemans, Rixensart, BE;
Pierre Duvivier, Rixensart, BE;
Inventors:
Ralph Leon Biemans, Rixensart, BE;
Pierre Duvivier, Rixensart, BE;
Assignee:
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/385 (2006.01); C07K 1/00 (2006.01); C07H 1/00 (2006.01); A61K 39/02 (2006.01); A61K 47/48 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
A61K 39/385 (2013.01); A61K 47/4833 (2013.01); A61K 47/48261 (2013.01); A61K 2039/627 (2013.01); A61K 2039/6037 (2013.01); Y10S 424/831 (2013.01); Y10S 530/807 (2013.01);
Abstract
The present application discloses a method for making an immunogenic composition comprising an improved way of conducting saccharide-protein conjugation reactions using carbodiimide condensation chemistry. Depending on the nature of the saccharide or protein carrier involved, the quality of the conjugate may be improved by adding one of the reaction components slowly to the reaction mixture. In addition, the conjugate is mixed with a staphylococcal antigen. Immunogenic compositions are further provided comprising the saccharide-protein conjugates made by the methods disclosed.