The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 07, 2014
Filed:
Aug. 16, 2011
Mangesh Narayan Rajadhyaksha, Mumbai, IN;
Ranjeet Nair, Mumbai, IN;
Sandip Kacharu Deshmukh, Mumbai, IN;
Somnath Ambadas Khabale, Mumbai, IN;
Aditi Milind Panandikar, Mumbai, IN;
Mangesh Narayan Rajadhyaksha, Mumbai, IN;
Ranjeet Nair, Mumbai, IN;
Sandip Kacharu Deshmukh, Mumbai, IN;
Somnath Ambadas Khabale, Mumbai, IN;
Aditi Milind Panandikar, Mumbai, IN;
Indoco Remedies Limited, Mumbai, IN (US);
Abstract
Disclosed herein is an improved process for the preparation of 3-[(2R,3R)-1-(dimethylamino)-2-methylpentan-3-yl]phenol of Formula-I and its pharmaceutically acceptable salt which comprises the reaction of (S)-1-(dimethylamino)-2-methylpentan-3-one of formula VIII with 3-bromo anisole of formula II under Grignard conditions to get the compound (2S,3R)-1-(dimethylamino)-3-(3-methoxyphenyl)-2-methyl pentan-3-ol of formula V followed by activation of the —OH group of the formula V to convert into sulfonate esters of formula IX, which are on reductive deoxygenation to yield (2R,3R)-3-(3-methoxyphenyl)-N,N,2-trimethylpentan-1-amine of formula VII and demethylation of formula VII to obtain the compound 3-[(2R,3R)-1-(dimethylamino)-2-methylpentan-3-yl]phenol of Formula-1.