The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 07, 2014
Filed:
Apr. 22, 2010
Tomas Hudlicky, St. Catharines, CA;
Robert Carroll, Stevenage, GB;
Hannes Leisch, Attersee, AT;
Ales Machara, Brevnov, CZ;
Lukas Werner, Kadan, CZ;
David R. Adams, Thorold, CA;
Tomas Hudlicky, St. Catharines, CA;
Robert Carroll, Stevenage, GB;
Hannes Leisch, Attersee, AT;
Ales Machara, Brevnov, CZ;
Lukas Werner, Kadan, CZ;
David R. Adams, Thorold, CA;
Brock University, Ontario, CA;
Abstract
The present application describes processes for the synthesis of morphinane and morphinone compounds, useful as pharmaceutical agents. Also included are novel intermediates useful in the preparation of these compounds. The process comprises quaternization of oripavine to provide a mixture of the R- and S-isomeric (at the nitrogen) quaternary salts. The R-isomer is readily isolated and converted to various N-(R)-morphinane and N-(S)-morphinone compounds. The R-isomer, S-isomer or a mixture of R- and S-isomers may be demethylated and converted to various morphinane and morphinone compounds.