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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 8853393 B1

PDFFull Text
Date of Patent:
Oct. 07, 2014

Filed:

Jul. 29, 2011

Intermediate for preparing tapentadol or analogues thereof

Applicants:

Ziao Xu, Anhui, CN;

Yuanhai Zhao, Anhui, CN;

Degang LI, Anhui, CN;

Xiaoxiang LI, Anhui, CN;

Inventors:

Ziao Xu, Anhui, CN;

Yuanhai Zhao, Anhui, CN;

Degang Li, Anhui, CN;

Xiaoxiang Li, Anhui, CN;

Assignee:

Anhui New Star Pharmaceutical Development Co., Ltd., Hefei, Anhui, CN;

Attorneys:

Tianhua Gu

Global IP Services

Primary Examiner:

Samantha Shterengarts

Int. Cl.
CPC ...
C07D 265/30 (2006.01); C07D 211/02 (2006.01); C07D 295/023 (2006.01); C07C 331/28 (2006.01); C07C 69/76 (2006.01); C07C 51/58 (2006.01); C07C 327/00 (2006.01); C07C 209/00 (2006.01); C07C 233/11 (2006.01); C07D 211/16 (2006.01); C07C 69/732 (2006.01); C07C 213/00 (2006.01); C07D 295/192 (2006.01); C07C 327/44 (2006.01); C07C 59/48 (2006.01); C07C 255/37 (2006.01); C07C 213/10 (2006.01); C07C 51/60 (2006.01); C07C 255/36 (2006.01); C07C 213/02 (2006.01); C07C 67/08 (2006.01); C07C 59/64 (2006.01); C07C 235/34 (2006.01); C07C 327/22 (2006.01); C07C 237/20 (2006.01); C07C 51/367 (2006.01); C07C 41/26 (2006.01); C07C 327/28 (2006.01); C07D 295/185 (2006.01); C07C 41/22 (2006.01); C07C 69/734 (2006.01); C07C 231/02 (2006.01); C07C 253/14 (2006.01);
U.S. Cl.
CPC ...
C07D 295/192 (2013.01); C07C 233/11 (2013.01); C07D 211/16 (2013.01); C07C 69/732 (2013.01); C07C 213/00 (2013.01); C07C 327/44 (2013.01); C07C 59/48 (2013.01); C07C 255/37 (2013.01); C07C 213/10 (2013.01); C07C 51/60 (2013.01); C07C 255/36 (2013.01); C07C 213/02 (2013.01); C07C 67/08 (2013.01); C07C 59/64 (2013.01); C07C 235/34 (2013.01); C07C 327/22 (2013.01); C07C 237/20 (2013.01); C07C 51/367 (2013.01); C07C 41/26 (2013.01); C07C 327/28 (2013.01); C07D 295/185 (2013.01); C07C 41/22 (2013.01); C07C 69/734 (2013.01); C07C 231/02 (2013.01); C07C 253/14 (2013.01);
Abstract

The invention discloses a novel intermediate for preparing tapentadol and analogues thereof, wherein the structural formula is shown as formula I or II, and the groups are defined as the specification. The invention further discloses a method for preparing the novel intermediate and use of the intermediate for preparing tapentadol and analogues thereof. The invention can remarkably improve the product yield and quality of tapentadol, reduce the production cost, and simplify the production procedure. The preparation process is environment friendly, thus more suitable for the requirements of industrial production.

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