The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 07, 2014
Filed:
Aug. 15, 2008
Ekambar Kandimalla, Southboro, MA (US);
Lakshmi Bhagat, Framingham, MA (US);
Mallikarjuna Putta, Burlington, MA (US);
Daqing Wang, Bedford, MA (US);
Sudhir Agrawal, Shrewsbury, MA (US);
Ekambar Kandimalla, Southboro, MA (US);
Lakshmi Bhagat, Framingham, MA (US);
Mallikarjuna Putta, Burlington, MA (US);
Daqing Wang, Bedford, MA (US);
Sudhir Agrawal, Shrewsbury, MA (US);
Idera Pharmaceuticals, Inc., Cambridge, MA (US);
Abstract
The invention relates to TLR9 antagonist compounds and their therapeutic or prophylactic use. The invention provides novel immune regulatory oligonucleotides and immunomers as antagonist of TLRs and methods of use thereof. These immune regulatory oligonucleotides have unique sequences that suppress, without completely ablating, TLR-mediated signaling in response to a TLR ligand or TLR signaling agonist. The methods may have use in the prevention and treatment of autoimmunity, inflammation, inflammatory bowel disease, lupus, allergy, asthma, infection, sepsis, cancer and immunodeficiency.