The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 07, 2014
Filed:
Oct. 19, 2007
Pedro Alfonso, Malvern, PA (US);
Michael Capaldi, Malvern, PA (US);
Dennis Dong, Berwyn, PA (US);
Thomas R. Gervais, Malvern, PA (US);
Joshua Goldstein, Malvern, PA (US);
Allen B. Magill, Malvern, PA (US);
Nicole Quinlan, Malvern, PA (US);
Deepak Saini, Malvern, PA (US);
Pedro Alfonso, Malvern, PA (US);
Michael Capaldi, Malvern, PA (US);
Dennis Dong, Berwyn, PA (US);
Thomas R. Gervais, Malvern, PA (US);
Joshua Goldstein, Malvern, PA (US);
Allen B. Magill, Malvern, PA (US);
Nicole Quinlan, Malvern, PA (US);
Deepak Saini, Malvern, PA (US);
Janssen Biotech, Inc., Horsham, PA (US);
Abstract
Methods useful for producing a solution of purified Fc peptide chains are disclosed. The methods employ protein A chromatography to separate high molecular weight, aggregated peptide chains comprising antibody Fc domains from lower molecular weight unaggregated peptide chains that also comprise antibody Fc domains. The solutions of purified Fc peptide chains obtained by the methods of the invention contain less than 5% aggregate and greater than 70% of the Fc peptide chains subjected to purification.