The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 07, 2014
Filed:
May. 21, 2003
Kathrin Tissot, Zurich, CH;
Stefan Ewert, Zurich, CH;
Adrian Auf Der Maur, Zurich, CH;
Alcide Barberis, Zurich, CH;
Dominik Escher, Rifferswil, CH;
Kathrin Tissot, Zurich, CH;
Stefan Ewert, Zurich, CH;
Adrian Auf Der Maur, Zurich, CH;
Alcide Barberis, Zurich, CH;
Dominik Escher, Rifferswil, CH;
Abstract
Compositions are provided, which can be used as frameworks for the creation of very stable and soluble single-chain Fv antibody fragments. These frameworks have been selected for intracellular performance and are thus ideally suited for the creation of scFv antibody fragments or scFv antibody libraries for applications where stability and solubility are limiting factors for the performance of antibody fragments, such as in the reducing environment of a cell. Such frameworks can also be used to identify highly conserved residues and consensus sequences which demonstrate enhanced solubility and stability.