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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 8853360 B1

PDFFull Text
Date of Patent:
Oct. 07, 2014

Filed:

Jun. 23, 2011

Engineered botulinum neurotoxin c1 with selective substrate specificity

Applicants:

Meyer B. Jackson, Madison, WI (US);

Dongsheng Wang, Madison, WI (US);

Inventors:

Meyer B. Jackson, Madison, WI (US);

Dongsheng Wang, Madison, WI (US);

Assignee:

Wisconsin Alumni Research Foundation, Madison, WI (US);

Attorney:

Quarles & Brady LLP

Primary Examiner:

Gary Nickol

Assistant Examiner:

Lakia Tongue

Int. Cl.
CPC ...
C07K 1/00 (2006.01); C07K 14/00 (2006.01); C07K 17/00 (2006.01); C12Q 1/02 (2006.01); A61K 39/08 (2006.01); C07H 21/04 (2006.01); C07K 14/33 (2006.01);
U.S. Cl.
CPC ...
C07K 14/33 (2013.01); G01N 2333/33 (2013.01);
Abstract

An isolated polypeptide comprising a botulinum neurotoxin C1 light chain having a modified amino acid sequence relative to the sequence of a wild-type botulinum neurotoxin C1 light chain is disclosed. The modified botulinum neurotoxin C1 light chain is capable of selectively cleaving syntaxin protein, but has substantially reduced or no activity against SNAP-25 as compared to wild type botulinum neurotoxin C1 light chain, and is thus useful as a research tool and in medical treatment.

Find Patent Forward Citations

Jackson, Meyer. (2014). Engineered botulinum neurotoxin c1 with selective substrate specificity (U.S. Patent No. 8853360). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/8853360

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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