The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 07, 2014
Filed:
Dec. 17, 2009
Applicants:
Richard Beliveau, Montreal, CA;
Denis Gingras, Montreal, CA;
Carine Nyalendo, Montreal, CA;
Inventors:
Assignee:
Angiochem, Inc., Montreal, CA;
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/55 (2006.01); C07K 4/00 (2006.01); C12N 9/64 (2006.01); A61K 38/48 (2006.01);
U.S. Cl.
CPC ...
A61K 38/4886 (2013.01); C12N 9/6491 (2013.01);
Abstract
Based on the discovery that a soluble polypeptide including a nonphosphorylatable form of the MT1-MMP cytoplasmic domain is capable of inhibiting MT1-MMP in a dominant negative manner, the present invention provides compositions including MT1-MMP inhibitors such as peptide inhibitors, and methods for treating diseases associated with MT1-MMP activity. Such diseases include cancer, arthritis, and heart disease, and vascular disease.