The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 07, 2014
Filed:
Aug. 05, 2010
Isao Kinoyama, Tokyo, JP;
Takehiro Miyazaki, Tokyo, JP;
Yohei Koganemaru, Tokyo, JP;
Takuya Washio, Tokyo, JP;
Wataru Hamaguchi, Tokyo, JP;
Isao Kinoyama, Tokyo, JP;
Takehiro Miyazaki, Tokyo, JP;
Yohei Koganemaru, Tokyo, JP;
Takuya Washio, Tokyo, JP;
Wataru Hamaguchi, Tokyo, JP;
Astellas Pharma Inc., Chuo-Ku, Tokyo, JP;
Abstract
[Object] An excellent agent for preventing or treating dementia, schizophrenia, and the like, based on serotonin 5-HTreceptor modulating action, is provided. [Means for Solution] It was confirmed that acylguanidine derivatives (the following formula I; any one of Z, Z, Z, Zand Zis nitrogen atom, and the others are carbon atoms) which have the characteristic structure in which the guanidine is bonded to one ring of the quinoline or isoquinoline via a carbonyl group, and a cyclic group is bonded to the other ring, exhibit potent 5-HTreceptor modulating actions and excellent pharmacological actions based on the 5-HTreceptor modulating action, and thus can be excellent agents for preventing or treating dementia, schizophrenia, bipolar disorder, or attention deficit hyperactivity disorder. Thus, the present invention has been completed.