The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 07, 2014

Filed:

Dec. 17, 2012
Applicant:

Portola Pharmaceuticals, Inc., So. San Francisco, CA (US);

Inventors:

Shawn M. Bauer, Pacifica, CA (US);

Jack W. Rose, San Mateo, CA (US);

Yonghong Song, Foster City, CA (US);

Qing Xu, Foster City, CA (US);

Mukund Mehrotra, Winnipeg, CA;

Wolin Huang, Foster City, CA (US);

Anjali Pandey, Fremont, CA (US);

Assignee:

Portola Pharmaceuticals, Inc., South San Francisco, CA (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A01N 43/54 (2006.01); A61K 31/505 (2006.01); C07D 403/12 (2006.01); C07D 417/14 (2006.01); C07D 403/14 (2006.01); C07D 401/12 (2006.01); C07D 213/82 (2006.01); C07D 417/12 (2006.01); C07D 239/48 (2006.01);
U.S. Cl.
CPC ...
C07D 417/14 (2013.01); C07D 403/12 (2013.01); C07D 403/14 (2013.01); C07D 401/12 (2013.01); C07D 213/82 (2013.01); C07D 417/12 (2013.01); C07D 239/48 (2013.01);
Abstract

The present invention is directed to compounds of formula I and tautomers and pharmaceutically acceptable salts thereof which are selective inhibitors of JAK. The present invention is also directed to intermediates used in making such compounds, the preparation of such a compound, pharmaceutical compositions containing such a compound, methods of inhibition JAK activity, and methods to prevent or treat a number of conditions mediated at least in part by JAK activity.


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