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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 8853199 B1

PDFFull Text
Date of Patent:
Oct. 07, 2014

Filed:

Oct. 12, 2011

Hydroxylated and methoxylated pyrimidyl cyclopentanes as akt protein kinase inhibitors

Applicants:

Ian S. Mitchell, Lafayette, CO (US);

James F. Blake, Longmont, CO (US);

Rui Xu, Longmont, CO (US);

Nicholas C. Kallan, Boulder, CO (US);

Dengming Xiao, Longmont, CO (US);

Keith Lee Spencer, Lyons, CO (US);

Josef R. Bencsik, Longmont, CO (US);

Eli M. Wallace, Lyons, CO (US);

Stephen T. Schlachter, Boulder, CO (US);

Anna L. Banka, Longmont, CO (US);

Jun Liang, Palo Alto, CA (US);

Brian Safina, Redwood City, CA (US);

Birong Zhang, Union City, CA (US);

Christine Chabot, San Mateo, CA (US);

Steven DO, San Jose, CA (US);

Inventors:

Ian S. Mitchell, Lafayette, CO (US);

James F. Blake, Longmont, CO (US);

Rui Xu, Longmont, CO (US);

Nicholas C. Kallan, Boulder, CO (US);

Dengming Xiao, Longmont, CO (US);

Keith Lee Spencer, Lyons, CO (US);

Josef R. Bencsik, Longmont, CO (US);

Eli M. Wallace, Lyons, CO (US);

Stephen T. Schlachter, Boulder, CO (US);

Anna L. Banka, Longmont, CO (US);

Jun Liang, Palo Alto, CA (US);

Brian Safina, Redwood City, CA (US);

Birong Zhang, Union City, CA (US);

Christine Chabot, San Mateo, CA (US);

Steven Do, San Jose, CA (US);

Assignees:

Array Biopharma, Inc., Boulder, CO (US);

Genentech, Inc., South San Francisco, CA (US);

Attorney:

Viksnins, Harris & Padys PLLP

Primary Examiner:

Susanna Moore

Int. Cl.
CPC ...
C07D 409/12 (2006.01); C07D 409/14 (2006.01); C07D 403/12 (2006.01); C07D 401/12 (2006.01); C07D 405/12 (2006.01); C07D 413/12 (2006.01); A61K 31/496 (2006.01); A61P 35/00 (2006.01); A61P 29/00 (2006.01); A61P 25/28 (2006.01); C07D 239/70 (2006.01);
U.S. Cl.
CPC ...
C07D 239/70 (2013.01); C07D 413/12 (2013.01); C07D 405/12 (2013.01); C07D 401/12 (2013.01); C07D 409/12 (2013.01); C07D 409/14 (2013.01); C07D 403/12 (2013.01);
Abstract

The present invention provides compounds, including resolved enantiomers, resolved diastereomers, solvates and pharmaceutically acceptable salts thereof, comprising the Formula I: Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.

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