The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 07, 2014
Filed:
Jul. 18, 2006
Applicants:
Jonathan S. Stamler, Chapel Hill, NC (US);
Jordan Gutterman, Houston, TX (US);
Inventors:
Jonathan S. Stamler, Chapel Hill, NC (US);
Jordan Gutterman, Houston, TX (US);
Assignee:
Duke University, Durham, NC (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/70 (2006.01); A61K 38/00 (2006.01); A61K 35/12 (2006.01); C07H 17/04 (2006.01); C12Q 1/26 (2006.01); C12P 33/00 (2006.01); C07K 1/113 (2006.01); A61K 47/48 (2006.01); G01N 33/50 (2006.01); C07K 1/107 (2006.01); C07H 15/24 (2006.01);
U.S. Cl.
CPC ...
A61K 47/48246 (2013.01); A61K 38/00 (2013.01); C07K 1/1133 (2013.01); G01N 33/5041 (2013.01); G01N 33/5011 (2013.01); A61K 47/48338 (2013.01); C07K 1/1077 (2013.01); C07H 15/24 (2013.01); G01N 33/5023 (2013.01);
Abstract
Avicins and other thioesterification agents are used to modify cysteine groups of signaling proteins in order to modify their activity. Pathologies associated with signaling proteins which are regulatable through this method are treated using these thioesterification agents. These pathologies include those involving proteins which modulate physiologic redox status of organisms including arthersclerosis, cancer, bacterial infection, inflammation, and neurological disorders.