The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 07, 2014

Filed:

Feb. 23, 2011
Applicants:

Yasuki Kato, Kashiwa, JP;

Atsushi Ishii, Kashiwa, JP;

Naoya Shibata, Kashiwa, JP;

Tatsuyuki Hayashi, Kashiwa, JP;

Kazunori Kataoka, Tokyo, JP;

Kanjiro Miyata, Tokyo, JP;

Nobuhiro Nishiyama, Tokyo, JP;

Inventors:

Yasuki Kato, Kashiwa, JP;

Atsushi Ishii, Kashiwa, JP;

Naoya Shibata, Kashiwa, JP;

Tatsuyuki Hayashi, Kashiwa, JP;

Kazunori Kataoka, Tokyo, JP;

Kanjiro Miyata, Tokyo, JP;

Nobuhiro Nishiyama, Tokyo, JP;

Assignee:

NanoCarrier Co., Ltd., Kashiwa-Shi, JP;

Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 47/48 (2006.01); C08G 69/10 (2006.01); C12N 15/11 (2006.01);
U.S. Cl.
CPC ...
C08G 69/10 (2013.01); A61K 47/48323 (2013.01); A61K 47/48215 (2013.01); C12N 2310/14 (2013.01); C12N 15/111 (2013.01); C12N 2320/32 (2013.01);
Abstract

The present invention provides a cationic polyamino acid suitable for a carrier that can form a stable complex with a nucleic acid under a physiological condition and release the nucleic acid in cells suitably. The cationic polyamino acid can associate with a nucleic acid and includes a cationic amino acid residue having a cationic group in a side chain and a hydrophobic amino acid residue having a hydrophobic group in a side chain. The cationic polyamino acid includes 1 to 20 units of the cationic amino acid residue and is represented by the following formula (1). The meaning of each symbol in the formula is as shown in the description.


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