The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 07, 2014
Filed:
May. 21, 2010
Barbara L. Hempstead, New York, NY (US);
Rosemary Kraemer, Brooklyn, NY (US);
Shahin Rafii, Great Neck, NY (US);
Phi Wiegn, New York, NY (US);
Michael J. Donovan, Brookline, MA (US);
Barbara L. Hempstead, New York, NY (US);
Rosemary Kraemer, Brooklyn, NY (US);
Shahin Rafii, Great Neck, NY (US);
Phi Wiegn, New York, NY (US);
Michael J. Donovan, Brookline, MA (US);
Cornell Research Foundation, Inc., Ithaca, NY (US);
Children's Medical Center Corporation, Boston, MA (US);
Abstract
The present invention relates to methods of inducing or inhibiting the angiogenic process and promoting vessel growth or stabilization in an organ by modulating the trk receptor pathway. The present invention also relates to a method for treating a pathological disorder in a patient which includes administering a trk receptor ligand or an inhibitor or expression or activity of a trk receptor ligand. The present invention also relates to a method of screening for a modulator of angiogenesis, vessel growth, or vessel stabilization. Another aspect of the present invention is a method of diagnosing or monitoring a pathological disorder in a patient which includes determining the presence or amount of a trk receptor ligand or activation of a trk receptor ligand in a biological sample.