The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 07, 2014

Filed:

May. 11, 2011
Applicants:

Motoichi Kurisawa, Singapore, SG;

Fan Lee, Singapore, SG;

Inventors:

Motoichi Kurisawa, Singapore, SG;

Fan Lee, Singapore, SG;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/36 (2006.01); A61P 7/04 (2006.01); C07K 14/75 (2006.01); C07K 14/475 (2006.01); A61L 27/22 (2006.01); C12P 21/06 (2006.01); C12N 5/071 (2010.01); A61L 27/52 (2006.01); A61K 38/48 (2006.01); C12N 5/00 (2006.01); C12P 21/00 (2006.01); A61K 9/00 (2006.01); A61L 27/38 (2006.01);
U.S. Cl.
CPC ...
A61K 9/00 (2013.01); A61L 27/225 (2013.01); C12P 21/06 (2013.01); C12N 2533/56 (2013.01); C12N 5/069 (2013.01); C12N 2533/80 (2013.01); A61L 27/52 (2013.01); C12N 2537/10 (2013.01); A61K 38/4833 (2013.01); C12N 5/0068 (2013.01); C12P 21/00 (2013.01); A61K 38/363 (2013.01); A61L 27/3808 (2013.01); C12Y 111/01007 (2013.01);
Abstract

There is provided a method of forming a hydrogel, the method comprising: providing a mixture of a polymer comprising a cross-linkable pendant phenolic group, peroxidase, HO, fibrinogen, and thrombin, at concentration sufficient to enzymatically cross-link the polymer and to cleave the fibrinogen to yield fibrin; and allowing the mixture to form a hydrogel. There is also provided a hydrogel comprising a cross-linked network of a polymer interpenetrated by fibrin fibers, the polymer cross-linked by oxidative coupling between phenolic groups pendant on the polymer.


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