The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 07, 2014
Filed:
Jun. 16, 2011
Fabien Cabirol, Dusseldorf, DE;
Anupam Gohel, Singapore, SG;
Seong Ho OH, Singapore, SG;
Derek Smith, Singapore, SG;
Brian Wong, Singapore, SG;
James Lalonde, Palo Alto, CA (US);
Fabien Cabirol, Dusseldorf, DE;
Anupam Gohel, Singapore, SG;
Seong Ho Oh, Singapore, SG;
Derek Smith, Singapore, SG;
Brian Wong, Singapore, SG;
James Lalonde, Palo Alto, CA (US);
Codexis, Inc., Redwood City, CA (US);
Abstract
The present disclosure provides engineered transaminase polypeptides having improved properties as compared to naturally occurring transaminases including the ability of converting the substrate, 3'-hydroxyacetophenone to (S)-3-(1-aminoethyl)-phenol in enantiomeric excess and high percentage conversion. Also provided are polynucleotides encoding the engineered transaminases, host cells capable of expressing the engineered transaminases, and methods of using the engineered transaminases to synthesize (S)-3-(1-aminoethyl)-phenol and related compounds useful in the production of active pharmaceutical ingredients.