The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 07, 2014
Filed:
Jun. 07, 2007
Applicants:
David F. Gardiner, Wayne, PA (US);
Yaoxing Huang, Brooklyn, NY (US);
Inventors:
David F. Gardiner, Wayne, PA (US);
Yaoxing Huang, Brooklyn, NY (US);
Assignees:
The Rockefeller University, New York, NY (US);
Cornell University, Ithaca, NY (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 39/00 (2006.01); A61K 39/38 (2006.01); A61K 39/08 (2006.01); C12N 15/00 (2006.01); C12N 1/20 (2006.01); C07H 21/04 (2006.01); C07K 14/33 (2006.01);
U.S. Cl.
CPC ...
C07K 14/33 (2013.01);
Abstract
In one aspect, the invention provides a DNA molecule. The DNA molecule includes a nucleotide sequence that encodes the receptor-binding domain oftoxin A or toxin B in which at least about 10% of the in-frame codons for each amino acid residue has a higher percentage use in the human genome than the corresponding in-frame codons oftoxin A or toxin B having a known sequence. Methods for generating antibodies totoxin A or toxin B, methods for reducing the risk of ainfection, and methods for treating aare also provided.