The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 07, 2014

Filed:

Nov. 17, 2010
Applicants:

Helen M. Blau, Menlo Park, CA (US);

Kostandin Pajcini, Philadelphia, PA (US);

Jason Pomerantz, Mill Valley, CA (US);

Inventors:

Helen M. Blau, Menlo Park, CA (US);

Kostandin Pajcini, Philadelphia, PA (US);

Jason Pomerantz, Mill Valley, CA (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 35/12 (2006.01); C12Q 1/02 (2006.01); C12N 5/00 (2006.01); C12N 5/077 (2010.01);
U.S. Cl.
CPC ...
C12N 5/0658 (2013.01); C12N 2501/40 (2013.01); C12N 2501/405 (2013.01);
Abstract

Methods are provided for producing cells within a lineage (lineage restricted cells) from post-mitotic differentiated cells of the same lineage ex vivo and in vivo, and for treating a subject in need of tissue regeneration therapy by employing these lineage-restricted cells. In addition, the production of lineage restricted cells from postmitotic tissues derived from patients with diseases allows for a characterization of pathways that have gone awry in these diseases and for screening of drugs that will ameliorate or correct the defects as a means of novel drug discovery. Also provided are kits for performing these methods.


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