The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 07, 2014

Filed:

Jul. 25, 2008
Applicants:

Hiroshi Handa, Yokohama, JP;

Mamoru Hatakeyama, Yokohama, JP;

Masanori Abe, Tokyo, JP;

Satoshi Sakamoto, Yokohama, JP;

Yuka Masaike, Yokohama, JP;

Kosuke Nishio, Yokohama, JP;

Yoshinori Kita, Yokohama, JP;

Hiroshi Kishi, Yokohama, JP;

Inventors:

Hiroshi Handa, Yokohama, JP;

Mamoru Hatakeyama, Yokohama, JP;

Masanori Abe, Tokyo, JP;

Satoshi Sakamoto, Yokohama, JP;

Yuka Masaike, Yokohama, JP;

Kosuke Nishio, Yokohama, JP;

Yoshinori Kita, Yokohama, JP;

Hiroshi Kishi, Yokohama, JP;

Assignee:
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 49/00 (2006.01); C09C 3/08 (2006.01); B22F 1/00 (2006.01); B82Y 30/00 (2011.01); A61K 49/18 (2006.01); C09C 1/24 (2006.01); C09C 3/10 (2006.01); G01N 33/543 (2006.01); B82Y 25/00 (2011.01); H01F 1/00 (2006.01); C09C 3/12 (2006.01); A61K 41/00 (2006.01);
U.S. Cl.
CPC ...
H01F 1/0045 (2013.01); G01G 49/00 (2013.01); C09C 3/08 (2013.01); B22F 1/0062 (2013.01); B82Y 30/00 (2013.01); A61K 49/1851 (2013.01); C09C 1/24 (2013.01); C09C 3/10 (2013.01); B22F 1/0022 (2013.01); G01N 33/54393 (2013.01); A61K 49/1854 (2013.01); A61K 49/1836 (2013.01); B82Y 25/00 (2013.01); A61K 49/1833 (2013.01); C09C 3/12 (2013.01); A61K 41/0052 (2013.01); A61K 49/183 (2013.01); C01P 2006/42 (2013.01);
Abstract

Nano-sized inorganic particles having uniform particle sizes and precisely controlled particle diameters have already been produced by synthesis in an organic solvent, but these nano-sized inorganic particles are hindered from dispersing in a polar solvent because of the adsorption of a long-chain fatty acid on the surfaces of the particles. Further, it was difficult to form nano-sized inorganic particles dispersible in a polar solvent by replacing the long-chain fatty acid coats. According to the invention, various surface-coated inorganic particles dispersible in polar solvents can be produced from fatty acid-coated inorganic particles by adding a temporary coating substance such as thiomalic acid to a nonpolar solvent containing fatty acid-coated inorganic particles dispersed therein to replace the fatty acid coats by the temporary coating substance, dispersing the inorganic particles coated with the temporary coating substance in a polar solvent, and then adding a coating substance dispersible in a polar solvent, e.g., citric acid to the obtained dispersion to replace the temporary coating substance coats covering the inorganic particles by the coating substance dispersible in a polar solvent.


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