The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 30, 2014
Filed:
Apr. 02, 2008
Christopher Dobson, Cambridgeshire, GB;
Fabrizio Chiti, Scandicci, IT;
Jesus Zurdo, Cambridgeshire, GB;
Christopher Dobson, Cambridgeshire, GB;
Fabrizio Chiti, Scandicci, IT;
Jesus Zurdo, Cambridgeshire, GB;
Abstract
A prediction method for predicting the effect of an amino acid modification on the rate of aggregation (solubility) of a reference polypeptide comprising: calculating the difference in hydrophobicity (ΔHydr) between the reference polypeptide and a modified polypeptide, calculating the difference in β-sheet propensity (ΔΔG+ΔΔG) between the reference polypeptide and modified polypeptide, calculating the difference in charge (Δ Charge) between the reference polypeptide and modified polypeptide, and calculating: [x* ΔHydr]+[y*(ΔΔG+ΔΔG)]−[z*Δ Charge], wherein x, y and z are scaling factors.