The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 30, 2014
Filed:
Mar. 03, 2006
Applicants:
Andrew Douglas Baxter, Cambridge, GB;
Kenneth Walter Sinden, Essex, GB;
Stefan Kleinebekel, Bielefeld, DE;
Inventors:
Andrew Douglas Baxter, Cambridge, GB;
Kenneth Walter Sinden, Essex, GB;
Stefan Kleinebekel, Bielefeld, DE;
Assignee:
Sosei R&D Ltd., London, GB;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 207/12 (2006.01);
U.S. Cl.
CPC ...
C07D 207/12 (2013.01);
Abstract
A method for the production of crystalline glycopyrronium bromide, comprises the reaction of glycopyrronium base with methyl bromide in a solvent, in which the solvent is selected such that the diastereoisomeric ratio of the product favors the R,S and S,R diastereoisomers over the R,R, and S,S diastereoisomers, and separating the desired diastereoisomers by one or more controlled crystallization steps. This method gives a product having a particle size of narrow distribution.