IDiyas

For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 8846947 B1

PDFFull Text
Date of Patent:
Sep. 30, 2014

Filed:

Jul. 02, 2009

Benzimidazoles and related analogs as sirtuin modulators

Applicants:

Chi B. VU, Cambridge, MA (US);

Jeremy S. Disch, Cambridge, MA (US);

Pui Yee NG, Cambridge, MA (US);

Charles A. Blum, Cambridge, MA (US);

Robert B. Perni, Cambridge, MA (US);

Inventors:

Chi B. Vu, Cambridge, MA (US);

Jeremy S. Disch, Cambridge, MA (US);

Pui Yee Ng, Cambridge, MA (US);

Charles A. Blum, Cambridge, MA (US);

Robert B. Perni, Cambridge, MA (US);

Assignee:

GlaxoSmithKline LLC, Wilmington, DE (US);

Attorneys:

Grace C. Hsu

Jeffrey A. Sutton

John Lemanowicz

Primary Examiner:

Laura L Stockton

Int. Cl.
CPC ...
A61K 31/4184 (2006.01); A61K 31/5377 (2006.01); A61K 31/506 (2006.01); A61K 31/501 (2006.01); A61K 31/497 (2006.01); A61K 31/4545 (2006.01); C07D 235/18 (2006.01); C07D 401/12 (2006.01); C07D 401/14 (2006.01); C07D 403/12 (2006.01); C07D 403/14 (2006.01); C07D 413/12 (2006.01); C07D 413/14 (2006.01); C07D 417/12 (2006.01); C07D 417/14 (2006.01); A61K 31/5355 (2006.01); C07D 471/08 (2006.01); C07D 405/12 (2006.01); A61K 31/437 (2006.01); C07D 405/14 (2006.01); A61K 31/495 (2006.01); A61K 31/427 (2006.01); A61K 31/4427 (2006.01); A61K 45/06 (2006.01); A61K 31/422 (2006.01); A61K 31/46 (2006.01); C07D 513/04 (2006.01); C07D 471/04 (2006.01);
U.S. Cl.
CPC ...
C07D 403/12 (2013.01); A61K 31/5355 (2013.01); C07D 401/12 (2013.01); C07D 471/08 (2013.01); C07D 413/12 (2013.01); C07D 405/12 (2013.01); A61K 31/437 (2013.01); C07D 403/14 (2013.01); C07D 405/14 (2013.01); A61K 31/495 (2013.01); C07D 417/12 (2013.01); C07D 413/14 (2013.01); A61K 31/427 (2013.01); A61K 31/4427 (2013.01); A61K 45/06 (2013.01); A61K 31/422 (2013.01); A61K 31/46 (2013.01); C07D 401/14 (2013.01); C07D 513/04 (2013.01); A61K 31/4184 (2013.01); C07D 417/14 (2013.01); C07D 471/04 (2013.01);
Abstract

Provided herein are sirtuin-modulating compounds of formula (II). The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders relating to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.

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