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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 8846853 B1

PDFFull Text
Expired
Date of Patent:
Sep. 30, 2014

Filed:

Nov. 03, 2011

Polycondensation of lactic acid for medical biodegradable polylactic acid catalyzed by creatinine

Applicants:

Hong LI, Jiangsu, CN;

Quanxing Zhang, Jiangsu, CN;

Wei Jiang, Jiangsu, CN;

Wei Huang, Jiangsu, CN;

Bingcai Pan, Jiangsu, CN;

Inventors:

Hong Li, Jiangsu, CN;

Quanxing Zhang, Jiangsu, CN;

Wei Jiang, Jiangsu, CN;

Wei Huang, Jiangsu, CN;

Bingcai Pan, Jiangsu, CN;

Assignee:

Nanjing University, Nanjing, Jiangsu, CN;

Attorney:

Rankin, Hill & Clark LLP

Primary Examiner:

Frances Tischler

Int. Cl.
CPC ...
C08G 63/08 (2006.01); A61K 47/32 (2006.01); C08G 63/82 (2006.01);
U.S. Cl.
CPC ...
C08G 63/823 (2013.01); A61K 47/32 (2013.01); C08G 63/08 (2013.01);
Abstract

A direct polycondensation method for medical biodegradable polylactic acid (PLA). The invention uses commercialized creatinine (a type of biomaterial organic guanidine compounds—the arginine metabolite creatinine in human body) as the catalyst and industrial lactic acid (mass content 85-90%, aqueous solution) as the monomer to synthesize the PLA in terms of second polycondensation without solvent. Instead of tin catalysts having cytotoxicity, the catalyst used in the invention has high biocompatibility and biosafety. The synthesized PLA does not contain any metal and other toxic components; therefore, it can be used as the carrier for targeting drugs and controlled release drugs. The green catalyst and green processing method (no solvent applied and no toxic products produced) are used to synthesize the green biodegradable PLA with high biosafety. The molecular weight distribution for all synthesized products is narrow and the molecular weight is controllable within 1.5-3.0×10.

Find Patent Forward Citations

Li, Hong. (2014). Polycondensation of lactic acid for medical biodegradable polylactic acid catalyzed by creatinine (U.S. Patent No. 8846853). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/8846853

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