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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 8846747 B1

PDFFull Text
Date of Patent:
Sep. 30, 2014

Filed:

Nov. 17, 2010

Compounds and methods for altering lifespan of eukaryotic organisms

Applicants:

David S. Goldfarb, Victor, NY (US);

Joseph A. Maddry, Birmingham, AL (US);

Lynn Rasmussen, Odenville, AL (US);

Ellie Lucille White, Birmingham, AL (US);

Krister Wennerberg, Helsinki, NO;

Inventors:

David S. Goldfarb, Victor, NY (US);

Joseph A. Maddry, Birmingham, AL (US);

Lynn Rasmussen, Odenville, AL (US);

Ellie Lucille White, Birmingham, AL (US);

Krister Wennerberg, Helsinki, NO;

Assignees:

University of Rochester, Rochester, NY (US);

Southern Research Institute, Birmingham, AL (US);

Attorneys:

David P. Halstead

Foley Hoag LLP

Primary Examiner:

Shirley V Gembeh

Int. Cl.
CPC ...
A61K 31/405 (2006.01); A61K 31/135 (2006.01); A61K 31/12 (2006.01); C07D 307/02 (2006.01); C07C 49/00 (2006.01); C07C 49/753 (2006.01); C07D 317/54 (2006.01); C07C 49/577 (2006.01); C07D 307/54 (2006.01); C07D 333/22 (2006.01); C07C 49/417 (2006.01); C07D 209/12 (2006.01); C07C 49/792 (2006.01); C07D 319/18 (2006.01); C07C 49/403 (2006.01); C07C 235/82 (2006.01); C07C 49/657 (2006.01); C07D 307/46 (2006.01); C07C 49/573 (2006.01); C07C 49/543 (2006.01); C07C 49/613 (2006.01); C07C 49/567 (2006.01); C07C 69/757 (2006.01); C07C 49/553 (2006.01); C07C 225/22 (2006.01); C07C 69/743 (2006.01);
U.S. Cl.
CPC ...
C07C 49/657 (2013.01); C07C 2102/42 (2013.01); C07C 49/753 (2013.01); C07D 317/54 (2013.01); C07C 49/577 (2013.01); C07D 307/54 (2013.01); C07D 333/22 (2013.01); C07C 49/417 (2013.01); C07D 209/12 (2013.01); C07C 49/792 (2013.01); C07D 319/18 (2013.01); C07C 2101/08 (2013.01); C07C 49/403 (2013.01); C07C 235/82 (2013.01); C07C 2101/02 (2013.01); C07D 307/46 (2013.01); C07C 49/573 (2013.01); C07C 49/543 (2013.01); C07C 2101/14 (2013.01); C07C 49/613 (2013.01); C07C 49/567 (2013.01); C07C 69/757 (2013.01); C07C 49/553 (2013.01); C07C 225/22 (2013.01); C07C 69/743 (2013.01);
Abstract

Provided are compounds which generally have a triketone structure. Examples of the compounds include derivatives of 1,3-cyclohexanedione, such as: 1,3-cyclohexanedione, 2-propanoyl-5-cyclohexyl-; 1,3-cyclohexanedione, 2-propanoyl-5-[4-fluorophenyl]-; 1,3-cyclohexanedione, 2-acetyl-5-[thien-2-yl]-; 1,3-cyclohexanedione, 2-acetyl-5-butyl-; and 1,3-cyclohexanedione, 2-propanoyl-5-[bicyclo[2.2.1]hept-2-en-5-yl]-. The compounds can be used to alter the lifespan of eukaryotic organisms and treat inflammation.

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